{"id":19819,"date":"2021-10-28T10:38:33","date_gmt":"2021-10-28T10:38:33","guid":{"rendered":"https:\/\/www.optometrists.org\/?page_id=19819"},"modified":"2021-10-28T10:38:33","modified_gmt":"2021-10-28T10:38:33","slug":"tonic-pupil-adie-syndrome","status":"publish","type":"page","link":"https:\/\/www.optometrists.org\/general-practice-optometry\/guide-to-eye-health\/conditions-that-affect-the-pupil\/tonic-pupil-adie-syndrome\/","title":{"rendered":"Tonic Pupil (Adie Syndrome)"},"content":{"rendered":"<h2><b>Adie syndrome is a relatively rare condition affecting 5 in every 100,000 people, most often young adults aged 25-45.\u00a0<\/b><\/h2>\n<p>Adie syndrome has multiple names:<\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\">Adie&#8217;s Pupil<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\">Adie&#8217;s Syndrome<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\">Adie&#8217;s Tonic Pupil<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\">Tonic pupil syndrome<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\">Holmes-Adie Syndrome (HAS)<\/li>\n<\/ul>\n<h2><b>What is Adie syndrome?<\/b><\/h2>\n<p>Adie syndrome is a neurological disorder that affects the autonomic nervous system, resulting in one pupil of the eye being larger than the other.<\/p>\n<p>It is distinguished by one eye having a larger-than-normal pupil that constricts slowly in bright light (tonic pupil), as well as the absence of deep tendon reflexes, most commonly in the Achilles tendon.<\/p>\n<h2><b>What causes Adie syndrome<\/b><\/h2>\n<p>In most cases, the cause of Adie syndrome is unknown. In some cases, it is genetically based and inherited from a parent or relative.<\/p>\n<p><b>The National Institute of Neurological Disorders and Stroke (NINDS): Adie syndrome results from inflammation or nerve damage in the ciliary ganglion in the brain, which is located right behind the eye<\/b>.<\/p>\n<p>This inflammation or damage to the nerves may arise from:<\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\">Tumors<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\">Infections<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\">Traumatic injuries<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\">Autoimmune conditions<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\">Complications from surgery<\/li>\n<\/ul>\n<p>Deep tendon reflexes, such as the Achilles or patellar reflexes, can also be lost as a result of nerve damage. Similar causes of damage to the dorsal root ganglion at the root of spinal nerves could result in a lack of response in these locations.<\/p>\n<p><b>Concerned you may have one pupil larger than the other, <a href=\"https:\/\/www.optometrists.org\/practice-search\/\">contact an eye doctor near you.<\/a><\/b><\/p>\n<p><strong>SEE RELATED: <\/strong><a href=\"https:\/\/www.optometrists.org\/general-practice-optometry\/guide-to-eye-exams\/eye-exams\/are-my-eye-pupils-different\/\">Are My Eye Pupils Different?<\/a><\/p>\n\n\t<div class=\"practice-search-widget\">\n\t\t<h3>Find an eye doctor near you<\/h3>\n\t\t\n\t<form class=\"practice-search-form practice-search-form-widget\" action=\"https:\/\/www.optometrists.org\/practice-search\/results\/\" method=\"get\">\n\n\t\t<input type=\"hidden\" name=\"distance\" value=\"100\" class=\"practice-search-distance\">\n\t\t<input type=\"hidden\" name=\"page\" class=\"practice-search-page\">\n\t\t<input type=\"hidden\" name=\"address_latitude\"><input type=\"hidden\" name=\"address_longitude\">\n\n\t\t<input type=\"text\" name=\"address\" class=\"practice-search-address\" placeholder=\"City, Surburb or Address\" value=\"\">\n\n\t\t\n\t\t\t<input type=\"hidden\" name=\"distance\" value=\"100\" class=\"practice-search-distance\">\n\n\t\t\n\n\t\t<button type=\"submit\" class=\"practice-search-button\">\n\t\t\t\t\t\t\t\t\t<svg width=\"19\" height=\"19\" viewBox=\"0 0 19 19\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path fill-rule=\"evenodd\" clip-rule=\"evenodd\" d=\"M10.6796 0.130005C9.15708 0.130059 7.66615 0.5646 6.38198 1.38258C5.09781 2.20057 4.07373 3.36803 3.43004 4.74783C2.78634 6.12763 2.54976 7.66246 2.74808 9.17205C2.9464 10.6816 3.57139 12.1033 4.54964 13.27L0.729639 17.08C0.6364 17.1732 0.562439 17.2839 0.511979 17.4058C0.461519 17.5276 0.435547 17.6581 0.435547 17.79C0.435547 17.9219 0.461519 18.0524 0.511979 18.1743C0.562439 18.2961 0.6364 18.4068 0.729639 18.5C0.917942 18.6883 1.17334 18.7941 1.43964 18.7941C1.5715 18.7941 1.70207 18.7681 1.82389 18.7177C1.94571 18.6672 2.0564 18.5932 2.14964 18.5L5.99964 14.62C7.35406 15.6038 8.98566 16.1324 10.6596 16.13C12.7814 16.13 14.8162 15.2871 16.3165 13.7869C17.8168 12.2866 18.6596 10.2517 18.6596 8.13C18.6596 6.00827 17.8168 3.97344 16.3165 2.47315C14.8162 0.97286 12.7814 0.130005 10.6596 0.130005H10.6796ZM10.6796 14.13C9.49295 14.13 8.33291 13.7781 7.34622 13.1188C6.35952 12.4595 5.59049 11.5225 5.13636 10.4261C4.68224 9.32975 4.56342 8.12335 4.79493 6.95946C5.02644 5.79558 5.59788 4.72648 6.437 3.88736C7.27611 3.04825 8.34521 2.4768 9.5091 2.24529C10.673 2.01378 11.8794 2.1326 12.9757 2.58673C14.0721 3.04085 15.0092 3.80989 15.6685 4.79658C16.3277 5.78328 16.6796 6.94332 16.6796 8.13C16.6796 9.7213 16.0475 11.2474 14.9223 12.3726C13.7971 13.4979 12.2709 14.13 10.6796 14.13Z\" fill=\"#fff\"\/><\/svg>\n\t\t\t\t\t<\/button>\n\n\t\t<button type=\"button\" class=\"practice-search-use-my-location\">\n\t\t\tSearch near me\n\t\t<\/button>\n\n\n\t<\/form>\n\n\n\n\t\t<\/div>\n\n\t\n<h2><b>Symptoms of Adie syndrome<\/b><\/h2>\n<p><b>The most common symptom of Adie syndrome is an abnormally<\/b><b> enlarged pupil <\/b><b>\u00a0in one of the eyes.<\/b><\/p>\n<p>In general, changes in light cause the pupils to shrink or expand. These modifications occur quickly to help our eyes see in a variety of light settings.<\/p>\n<p>In Adie syndrome, the pupil usually remains dilated even in the presence of bright light.<\/p>\n<p>Symptoms in the affected eye sometimes include:<\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\">Blurred vision<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\">Impaired vision<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\">Trouble with depth perception<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\">Light sensitivity or the presence of \u2018light glares\u2019<\/li>\n<\/ul>\n<p>The symptoms of Adie syndrome usually only affect one eye. They may, however, eventually involve both eyes.<\/p>\n<h2><b>Additional symptoms<\/b><\/h2>\n<p>In addition to ocular symptoms, Adie syndrome is characterized by sluggish or missing deep tendon reflexes. Deep tendon reflexes are muscle reactions that are automatic and involuntary, such as knee reflexes and the Achilles tendon reflex.<\/p>\n<p>Additional symptoms that a person may experience include:<\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\">Headaches<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\">Pain in the face<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\">Mood swings<\/li>\n<\/ul>\n<p>A person may experience changes in sweating, which can be excessive or reduced in some circumstances.<\/p>\n<p><b>Ross\u2019s Syndrome:<\/b> While Ross&#8217;s syndrome is technically the combination of decreased sweating, missing reflexes, and weak pupil responses, some clinicians may describe this condition as a variant of Adie syndrome.<\/p>\n<p>Although the symptoms of Adie syndrome are rarely severe or disabling, they can cause significant disruption in everyday life and require treatment.<\/p>\n<h2><b>How to treat Adie syndrome<\/b><\/h2>\n<p>The type of treatment a person with Adie syndrome receives is determined by the symptoms they are experiencing.<\/p>\n<p>Doctors may provide eye drops containing pilocarpine, a medicine that might help constrict a pupil that has become too dilated.<\/p>\n<p>Light glare and depth perception may be improved as a result of restricting the size of the affected pupil.<\/p>\n<p>Others may require the use of prescription glasses or a modification in their prescription to help adjust and compensate for vision loss.<\/p>\n<p>If medication does not work, people who also suffer with excessive sweating may need a treatment called a thoracic sympathectomy.<\/p>\n<p>Other symptoms, such as absent or delayed reflexes, may be permanent.<\/p>\n<p><b><a href=\"https:\/\/www.optometrists.org\/practice-search\/\">Schedule an appointment with an eye doctor near you,<\/a> who can diagnose Adie syndrome.<\/b><\/p>\n<p><strong>LEARN MORE:<\/strong><a href=\"https:\/\/www.optometrists.org\/general-practice-optometry\/guide-to-eye-health\/\">\u00a0Guide to Eye Health<\/a><\/p>\n<p><i>If you notice one eye having a larger-than-normal pupil that constricts slowly in bright light &#8211; you may Adie\u2019s syndrome.<\/i><\/p>\n<p><i>This can be treated with eye drops or other optical options.<\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Adie syndrome is a relatively rare condition affecting 5 in every 100,000 people, most often young adults aged 25-45.\u00a0 Adie syndrome has multiple names: Adie&#8217;s<\/p>\n","protected":false},"author":1206,"featured_media":19834,"parent":19821,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-article.php","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-19819","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.9 - 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